22 - 16

(Dec 25, 2021 · Week 16)

Kyler Murray kept it himself on the read option and that's when things got interesting. Cutting it up the field before dipping back toward the middle of the field for the first down, it became a foot race in Colts territory as he split three defenders and made a push toward the goal line. He was pulled down inside the Indianapolis five-yard line for a gain of 57 yards. The Cardinals would score two plays later. Murray carried the ball four times for 74 yards and completed 27 of his 43 passes for 245 yards and a touchdown in Arizona's 22-16 loss to the Colts on Dec. 25, 2021.

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